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TABLE OF CONTENTS | REFERENCES | GLOSSARY
Hydrochloric Acid
(betaine hydrochloride)
General Description
Hydrochloric acid is found naturally in the gastric juices in the stomach, where it is needed to convert the enzyme pepsinogen into pepsin, an active enzyme that breaks down proteins for further digestion in the small intestine. Produced by the cells lining the stomach, hydrochloric acid also helps protect the digestive tract from bacterial infections. Hydrochloric acid is available as a dietary supplement in the form of betaine hydrochloride, which is a hydrochloric salt of betaine, a natural compound first isolated from sugar beets, but now known to be present in many plants and animals.

Health Applications

  • Digestive support
  • Gastrointestinal health

Primary Uses
Betaine hydrochloride supplements are used to increase stomach acidity in people with insufficient levels of stomach acid (hypochlorhydria). In most people, the cells lining the stomach produce all the acid necessary for healthy digestion; however, various factors can impede natural acid production, resulting in poor protein digestion, reduced absorption of vitamin B-12 and certain minerals, and increased susceptibility to bacterial overgrowth in the upper gut.4 Hypochlorhydria is most common in the elderly,3,4 as the body's ability to produce hydrochloric acid delines with age. Reduced stomach acid secretion has been associated with infection by Helicobacter pylori,1,5 a gastrointestinal bacterial pathogen that damages acid-producing cells. Some researchers believe that Helicobacter pylori is responsible for most cases of chronic hypochlorhydria.1,5

Dosage/Toxicity
Betaine hydrochloride supplements should only be taken under a doctor's supervision by people with diagnosed hypochlorhydria. Prescribed doses are typically taken with or immediately following protein-containing meals. Self medicating with betaine hydrochloride is strongly discouraged, as excessive hydrochloric acid can damage the stomach lining.


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